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Squamous Cell CarcinomaSquamous cell carcinoma, non-melanoma skin cancer

The second most common form of non-melanoma skin cancer and its close link to sun exposure.

In short: Squamous cell carcinoma, alongside basal cell carcinoma, is the second most common form of non-melanoma skin cancer. Its occurrence is closely linked to cumulative sun exposure, and actinic keratoses are a direct precursor. It often appears as rough, scaly or keratotic nodules or plaques that can bleed and may be mistaken for warts — have new or non-healing lesions assessed.

Overview

Squamous cell carcinoma, alongside basal cell carcinoma, is the second most common form of non-melanoma skin cancer. Unlike basal cell carcinoma, its occurrence is very directly linked to cumulative sun exposure over a lifetime; accordingly, UV-typical mutations in the p53 gene are found in practically all squamous cell carcinomas. Actinic keratoses are considered a direct precursor.

Squamous cell carcinomas often appear as rough, scaly or keratotic nodules or plaques that can bleed easily. They are not infrequently mistaken for common warts, which is why any newly appeared, growing or non-healing “wart” on the face should always be assessed by a GP or dermatologist.

Treatment Options

Excision (standard treatment)

As with basal cell carcinoma, surgical removal with a safety margin is the standard treatment, generally carried out in two stages: definitive wound closure only follows once tumour-free margins have been confirmed microscopically.

Mohs surgery (exceptional cases)

For more aggressive subtypes or in the T-zone of the face — particularly the nose, eyebrows and eye area — Mohs micrographic surgery is used in exceptional cases to achieve complete margin control with a maximally tissue-sparing approach.

Consistent follow-up care also applies after treatment of a squamous cell carcinoma: an annual full-body skin cancer screening, along with the proactive prevention programmes of the Dermetrics concept, to help prevent the development of new actinic keratoses and further skin cancer lesions.

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